Appeasing the Carotid Body After Chronic Intermittent Hypoxia

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Appeasing the Carotid Body After Chronic Intermittent Hypoxia.

I recall vividly a conversation with the late Professor C. John Dickinson DM, FRCP, ARCO (Professor of Medicine and Chairman of the Department of Medicine at St. Bartholomew’s Hospital, London, 1975–1992) who remarked that in the majority of cases cardiovascular pathology occurred at night while asleep. John’s great hypothesis was that a shortage of oxygen to the brain because of high cerebrova...

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Appeasing the Carotid Body After Chronic Intermittent Hypoxia

I recall vividly a conversation with the late Professor C. John Dickinson DM, FRCP, ARCO (Professor of Medicine and Chairman of the Department of Medicine at St. Bartholomew’s Hospital, London, 1975–1992) who remarked that in the majority of cases cardiovascular pathology occurred at night while asleep. John’s great hypothesis was that a shortage of oxygen to the brain because of high cerebrova...

متن کامل

Appeasing the Carotid Body After Chronic Intermittent Hypoxia

I recall vividly a conversation with the late Professor C. John Dickinson DM, FRCP, ARCO (Professor of Medicine and Chairman of the Department of Medicine at St. Bartholomew’s Hospital, London, 1975–1992) who remarked that in the majority of cases cardiovascular pathology occurred at night while asleep. John’s great hypothesis was that a shortage of oxygen to the brain because of high cerebrova...

متن کامل

Appeasing the Carotid Body After Chronic Intermittent Hypoxia

I recall vividly a conversation with the late Professor C. John Dickinson DM, FRCP, ARCO (Professor of Medicine and Chairman of the Department of Medicine at St. Bartholomew’s Hospital, London, 1975–1992) who remarked that in the majority of cases cardiovascular pathology occurred at night while asleep. John’s great hypothesis was that a shortage of oxygen to the brain because of high cerebrova...

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Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia.

Obstructive sleep apnea causes chronic intermittent hypoxia (IH) and is associated with impaired glucose metabolism, but mechanisms are unknown. Carotid bodies orchestrate physiological responses to hypoxemia by activating the sympathetic nervous system. Therefore, we hypothesized that carotid body denervation would abolish glucose intolerance and insulin resistance induced by chronic IH. Male ...

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ژورنال

عنوان ژورنال: Hypertension

سال: 2016

ISSN: 0194-911X,1524-4563

DOI: 10.1161/hypertensionaha.116.07377